Specific tumor targeting and activation of Vγ9Vδ2 T cells by bi-specific nanobodies

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Specific tumor targeting and activation of Vγ9Vδ2 T cells by bi-specific nanobodies

Gamma delta T cells expressing the Vg9Vδ2 T cell receptor (TCR) are the most predominant gδ-T cell subset in peripheral blood accounting for approximately 1-5 % of all T cells. Vg9Vδ2 T cells recognize phosphoantigens (pAg) such as isopentenyl pyrophosphate (IPP), a naturally occurring pAg that can accumulate in tumor cells, resulting in activation, cytokine release and anti-tumor activity of V...

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Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.

Vγ9Vδ2-T cells constitute the predominant subset of γδ-T cells in human peripheral blood and have been shown to play an important role in antimicrobial and antitumor immune responses. Several efforts have been initiated to exploit these cells for cancer immunotherapy, e.g. by using phosphoantigens, adoptive cell transfer, and by a bispecific monoclonal antibody based approach. Here, we report t...

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ژورنال

عنوان ژورنال: Journal for ImmunoTherapy of Cancer

سال: 2014

ISSN: 2051-1426

DOI: 10.1186/2051-1426-2-s3-p127